ICON Group International

Introduction

Ever need a fact or quotation on exons? Designed for speechwriters, journalists, writers, researchers, students, professors, teachers, historians, academics, scrapbookers, trivia buffs and word lovers, this is the largest book ever created for this single word. It represents a compilation from a variety of sources with a linguistic emphasis on anything relating to the term “exons,” including non-conventional usage and alternative meanings which capture ambiguities. The entries cover all parts of speech (noun, verb, adverb or adjective usage) as well as use in modern slang, pop culture, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This “data dump” results in many unexpected examples for exons, since the editorial decision to include or exclude terms is purely a linguistic process. The resulting entries are used under license or with permission, used under “fair use” conditions, used in agreement with the original authors, or are in the public domain. Proceeds from this book are used to expand the content and coverage of Webster’s Online Dictionary (www.websters-online-dictionary.org).

Description

Ever need a fact or quotation on "exons"? Designed for speechwriters, journalists, writers, researchers, students, professors, teachers, historians, academics, scrapbookers, trivia buffs and word lovers, this is the largest book ever created for this word. It represents a compilation of "single sentences" and/or "short paragraphs" from a variety of sources with a linguistic emphasis on anything relating to the term "exons," including non-conventional usage and alternative meanings which capture ambiguities. This is not an encyclopedic book, but rather a collage of statements made using the word "exons," or related words (e.g. inflections, synonyms or antonyms). This title is one of a series of books that considers all major vocabulary words. The entries in each book cover all parts of speech (noun, verb, adverb or adjective usage) as well as use in modern slang, pop culture, social sciences (linguistics, history, geography, economics, sociology, political science), business, computer science, literature, law, medicine, psychology, mathematics, chemistry, physics, biology and other physical sciences. This data dump results in many unexpected examples for "exons," since the editorial decision to include or exclude terms is purely a computer-generated linguistic process. The resulting entries are used under license or with permission, used under fair use conditions, used in agreement with the original authors, or are in the public domain.

Excerpt

Nonfiction Usage

Patent Usage

Cell Adhesion-Mediating Proteins and Polynucleotides Encoding Them: Patented by Karen A. Stark, Alix Weaver, Heidi M. Hoffmann, Raul Krauss, Dario B. Valenzuela and Kulvinder S. Saini on May 7, 2002. Abstract: The present invention provides multiple polynucleotide sequences from the same novel gene, the exons comprising the polynucleotide sequences, and the proteins encoded by the polynucleotide sequences. Three splicing variant polynucleotides were isolated from prostate tissue. The polypeptides, including the splicing variants, have a region of hydrophobicity indicative of a transmembrane domain and all three extracellular and cytoplasmic domains.

Dax-1 Protein, Methods for Production and Use Thereof: Patented by Edward R. Mccabe B., Weiwen Guo, Thomas P. Burris and Eric Vilain on July 26, 1996. Abstract: The invention provides a DAX-1 protein molecule having the amino acid sequence beginning with methionine at position 1 and ending with isoleucine at position 470 as shown in Figure 12. The invention further provides the genomic nucleic acid sequence for DAX-1, including intron, exons and a promoter region. Additionally, the invention provides methods for using and making the DAX-1 protein and DAX-1 nucleic acid molecules.

Detection of mutations in the human ATM gene: Patented by Patrick Concannon on November 1, 1996. Abstract: This invention pertains to methods for detecting mutations in the human ataxia telangiectasia (ATM) gene. The invention provides DNA sequences immediately flanking the exons in the 3' half of the gene. Also provided are primers that can be used in the polymerase chain reaction to amplify segments of the ATM gene corresponding to each of the 65 coding exons including its immediately flanking sequences. A number of mutations found in the human ATM gene are described also.

Gene encoding HM1.24 antigen protein and promoter thereof: Patented by Toshihiko Ohtomo, Masayuki Tsuchiya, Yasuo Koishihara and Masaaki Kosaka on August 4, 2000. Abstract: There are provided a genomic DNA comprising 4 exons encoding the amino acid sequence as set forth in SEQ ID NO: 2 and 3 introns ligating them, and a splicing variant of said genomic DNA; as well as a DNA having the base sequence as set forth in SEQ ID NO: 4 and a promoter activity and the fragment thereof, and uses thereof.

Gene for Peripheral Arterial Occlusive Disease: Patented by Gudmundur Gudmundsson on January 29, 2003. Abstract: A role of the human PAOD1 gene, a. k. a. prostaglandin E receptor subtype EP3 or PTGER3, in peripheral arterial occlusive disease is disclosed, as are nucleic acids encoding several subtypes of the receptor comprising novel exons 4 and 5. Methods for diagnosis, prediction of clinical course and treatment for peripheral occlusive disease using polymorphisms in the PAOD1 gene are also disclosed.

Gene related to migraine in man: Patented by Rune Robert Frants, Michel Dominique Ferrari, Gisela Marie Terwindt and Roel Andre Ophoff on March 6, 1999. Abstract: Genes for familial hemeplegic migraine (FHM), episodic ataxia type-2 (EA-2), common forms of migraine, and other episodic neurological disorders, such as epilepsy, have been mapped to chromosome 19p13. A brain-specific P/Q type calcium channel subunit gene, covering 300 kb with 47 exons is provided. The exons and their surroundings reveal polymorphic variations and deleterious mutations that are linked to various types of cation channel dysfunctions causing episodic neurological disorders in man or animals.

Genomic Gene Encoding Hm1.24 Antigen Protein and Promoter Thereof: Patented by Toshihiko Ohtomo, Masayuki Tsuchiya, Yasuo Koishihara and Masaaki Kosaka on February 25, 1999. Abstract: A genomic DNA encoding the amino acid sequence represented by SEQ ID NO:2 and consisting of 4 exons and 3 introns connecting the same, and a splicing variant of this genomic DNA; and a DNA having a base sequence represented by SEQ ID NO:4 and having a promoter activity, a fragment thereof and utilization of the same.

Method and System for Identifying Splice Variants of a Gene: Patented by Jonathan Bingham and Subha Srinivasan on July 25, 2002. Abstract: A method and system for identifying mRNA present in a sample. A splice variant technique selects a set of possible exon-exon junctions based on exons of expected mRNA transcripts. The splice varianttechnique then selects indicator polynucleotides for the exon-exon junctions and detects the expressionlevel of the indicator polynucleotides in the sample. The splice variant technique then may use a mathematical algorithm to identify possible splice variants in the sample from the observed expressionlevels.

Methods for screening for mutations at various positions in the introns and exons of the cystic fibrosis gene: Patented by Lap-Chee Tsui, Johanna M. Rommens and Bat-sheva Kerem on June 6, 1995. Abstract: The cystic fibrosis gene and its gene product are described for mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, cloning of the gene and manufacture of the protein, and development of cystic fibrosis affected animals.

Methods for the Diagnosis, Prognosis and Treatment of Glaucoma and Related Disorders: Patented by Thai D. Nguyen, Jon R. Polansky, Pu Chen and Hua Chen on January 9, 1998. Abstract: The nucleic acid upstream of the TIGR protein encoding sequence can be used to diagnose glaucoma. Polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to diagnose glaucoma. In addition, polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to prognose glaucoma.